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  1. ; ; ; (, Microbiology spectrum)
    Jin, Q; Wu, Q; Shapiro, B; McKernan, S. (Ed.)
    The Monodequationhasbeenwidelyappliedasthegeneralratelaw of microbialgrowth,butitsapplicationsarenotalwayssuccessful.Bydrawingon the frameworksofkineticandstoichiometricmetabolicmodelsandmetaboliccon- trol analysis,themodelingreportedheresimulatedthegrowthkineticsofametha- nogenic microorganismandillustratedthatdifferentenzymesandmetabolitescon- trol growthratetovariousextentsandthattheircontrolspeakateitherverylow, intermediate, orveryhighsubstrateconcentrations.Incomparison,withasingle term andtwoparameters,theMonodequationonlyapproximatelyaccountsforthe controls ofrate-determiningenzymesandmetabolitesatveryhighandverylow substrate concentrations,butneglectstheenzymesandmetaboliteswhosecontrols are mostnotableatintermediateconcentrations.These findings supportalimited link betweentheMonodequationandmethanogengrowth,andunifythecompet- ing viewsregardingenzymerolesinshapinggrowthkinetics.Theresultsalsopre- clude amechanisticderivationoftheMonodequationfrommethanogenmetabolic networks andhighlightafundamentalchallengeinmicrobiology:single-termexpres- sions maynotbesufficient foraccuratepredictionofmicrobialgrowth. 
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